Group update!

Stephen and Mingshuo's improved synthesis of the pleuromutilin core is published!

Our Perspective on gut microbiome-associated colorectal cancer is published!

Our Account of the mechansim of action of lomaiviticin A is published!

Seth has been awarded the 2018 Tetrahedron Young Investigator Award and the 2018 Elias J. Corey Award for Outstanding Original Contribution in Organic Synthesis by a Young Investigator.

Goodbye, old friend

To our beloved LC/MS -

We are so sad to see you go. Words can not capture the affection we have for you. From the very beginning, you've been a stalwart member of the group. When times were tough, you were always there to give us 90 seconds of your time. We pushed you to the limit of your capabilities...and then pushed some more. You will never be forgotten. You are the Picasso of separations.

Godspeed, old friend.


Herzon Group

Spotlight on recent papers

In collaboration with the Crawford group, we recently published a paper containing further insights into colibactin biosynthesis. This paper establishes that colibactins derive from fully linear precolibactin precursors that are liberated from the NRPS–PKS biosynthetic machinery. These linear precursors undergo varied cyclization pathways that depend on the presence or absence of the colibactin peptidase ClbP. This paper reported detection of the colibactin unsaturated imines in ClbP-proficient strains for the first time. Finally, a general method to elucidate domain dependencies in polyketide biosynthesis developed by the Crawford lab is reported. Congratulations Alan, Eric, and Emilee!

Our full paper describing the intermolecular hydroheteroarylation of unactivated alkenes by hydrogen atom transfer was also published. The hydropyridylation we recently developed was extended to imidazole, pyridine, quinoline, isoquinoline, and pyridazine-based hetereoarenium salts. We show that these salts are useful reagents in other Minisci-type couplings. Finally we describe the site-selective hydroheteroarylation of polyenes. Congratulations Xiaoshen, John, and Hester!

We also published a paper describing synthetic and computational studies of the antimalarial alkaloids known as the ocimicides. Detailed high-level NMR calculations in conjunction with spectroscopic analysis of our advanced synthetic intermediates suggest that the report structures of the metabolites are in need of revision. Congratulations Herman and Freddy and thanks to Choukri Ben Mamoun and Paul Rablen for a great collaboration!

Finally Stephen and Mingshuo's synthesis of 12-epi-mutilins was recently published. This work lays the foundation for the production of novel antibiotics active against Gram-negative and drug-resistant pathogens. Congratulations Stephen and Mingshuo!

Thank you everyone for all of your hard work!