Seth was born in Philadelphia, Pennsylvania in 1979. He grew up in Cheltenham, just outside the city, and in 1997 graduated from Valley Forge Military Academy (Wayne, PA). In 1998, he began his undergraduate studies at Temple University (Philadelphia, PA). There he conducted research in the laboratories of Professor Grant R. Krow, studying the synthesis and chemistry of highly strained azabicyclohexanes [such as N-(tert-butoxycarbonyl)-2-azabicylo[2.1.1]hexane]. In 2002 he moved to Cambridge, MA to begin his graduate studies at Harvard University. Under the guidance of Professor Andrew G. Myers, he developed enantioselective syntheses of the complex antiproliferative alkaloids avrainvillamide and stephacidin B. After graduating in 2006, he moved to the University of Illinois, Urbana-Champaign, to begin postdoctoral studies with Professor John F. Hartwig. At the U of I he was engaged in the study of new transition metal-mediated C–H bond functionalization reactions and the development of new methods for reaction discovery. In 2008 he joined the Yale Chemistry Department as an Assistant Professor of Chemistry. In 2012 he was appointed to Associate Professor of Chemistry and in 2013 was appointed to Professor of Chemistry.
Daniel Arnold, Graduate Student
BA, 2014, College of the Holy Cross
Born and raised in the suburbs of Boston, Massachusetts, Dan received his undergraduate education at College of the Holy Cross in Worcester, Massachusetts where he studied regioselective, organocatalytic ring-openings of lactones under the mentorship of Professpr Brian Linton. After graduating and failing to walk on to the New England Patriots roster as the starting quarterback, Dan decided to pursue his PhD in chemistry at Yale. Aside from chemistry, Dan enjoys playing ultimate frisbee, weight-lifting and cats.
Dr. Hester Dang, Postdoctoral Associate
Ph.D., 2016, University of Washington
Christos Economou, Graduate Student
BS, The University of Chicago, 2013
Olivia Goethe, Graduate Student
B.S., 2016, Michigan State University
Olivia grew up on her parent's farm in Kalamazoo, MI, and attended Michigan State University. She worked in the lab of Kevin Walker and graduated in 2016 with a B.S. in Biochemistry. During her time in college, she held internships in process and synthetic chemistry at Zoetis VMRD, and Kalexsyn, Inc. In her free time, Olivia enjoys piano, drawing, hiking, and chocolate.
Dr. Alan Healy, Postdoc
PhD, 2014, University of St Andrews, Prof Nick Westwood
Born and raised in Ireland, Alan attended Trinity College Dublin where he obtained a degree in Medicinal Chemistry. Following this he was awarded a Cancer Research UK PhD studentship to pursue the development of novel anti-cancer drugs. This involved a MSc in Biomedical Science from the University of Edinburgh followed by a PhD in organic and medicinal chemistry from the University of St Andrews. His PhD research involved the development of small molecule modulators of cancer relevant protein-protein interactions and the total synthesis of two natural products, harzianic acid and JBIR-22. Alan took up a position at Yale in 2015, with a focus on the total synthesis and biological assessment of novel DNA-damaging natural products.
Ryan Holmes, Graduate Student
BS, 2015, Worcester Polytechnic Institute
Born and raised just south of Worcester, Massachusetts, Ryan attended WPI where he received his undergraduate degree in chemistry. While studying in Worcester, he spent time researching methods for single DNA fiber analysis using bio-orthogonal chemistry and functionalized thymidine analogues under the mentorship of Nicholas Rhind at the University of Massachusetts Medical School. Following graduation, Ryan went on to pursue a PhD in chemistry at Yale University under Seth Herzon. If not in the lab, he can be found either skiing at Smuggler’s Notch, kayaking, or fishing.
Ph.D., 2014, Korea Advanced Institute of Science and Technology
Seewon was born in Seoul, Korea, and moved to Daejeon to attend KAIST for his undergraduate studies in Chemistry. As a graduate student at KAIST, he studied natural product synthesis with Prof. Hee-Yoon Lee. Seewon conducted two years of postdoctoral study at KAIST in the lab of Prof. Sukbok Chang, where he investigated hydrosilylation reactions. He then joined the Herzon Lab to synthesize chemical derivatives of natural products for anticancer drugs.
Subham, Mahapatra, Postdoctoral Fellow
Dr. Stephen K. Murphy, Postdoctoral Fellow
BSc 2010, Queen’s University
PhD 2015, University of Toronto
Stephen was born and raised in Picton, Ontario, Canada and attended Queen’s University for his undergraduate studies in Chemistry. He was awarded an NSERC CGS-D scholarship to pursue his doctoral work at the University of Toronto with Dr. Vy Dong. He moved with the research group in 2012 to the University of California at Irvine and completed his studies there. During this PhD work, he developed new Rh- and Ru-catalyzed hydroacylation and transfer hydroformylation reactions. He joined the Herzon lab as an NSERC postdoctoral fellow in Spring 2015.
John A. Rose, Graduate Student
John hails from Fort Wayne, Indiana, and attended Indiana University in Bloomington for his undergraduate studies. There he conducted research in analytical organic electrochemistry, receiving awards for academic achievement and to help support pursuing research, including the William G. Roessler Scholarship, Earl G. Sturdevant Summer Research Scholarship, and James C. White Award. His undergraduate work ignited an interest in organic synthesis, and he decided to continue his studies and pursue a Ph.D.at Yale. John joined the Herzon Group in 2016.
Thomas Smeltzer, Graduate Student
Tom was born and raised in Michigan on his family’s farm. He attended Hope College for undergrad, where in addition to completing a BS in chemistry, he ran cross country and track. He moved to New Haven to study organic chemistry.
Martin Tomanik, Graduate Student
A.B., Dartmouth College, 2015
Martin was born in small town Prerov, Czech Republic. At 16, Martin decided to take a new direction and continue his education in the United States. After completing his exchange student year at Lebanon High School in New Hampshire, Martin began undergraduate studies at Dartmouth College. At Dartmouth, Martin gained research experience under the mentorship of Professor Jimmy Wu, synthesizing novel small molecule GLP-1 secretagogues possessing cycloalka[b]indole structural architecture. After graduation, Martin spent a year working as a strategy healthcare consultant for Putnam Associates, and then decided to pursue a Ph.D. at Yale, where his working on a natural product synthesis. Outside of lab, Martin enjoys playing ice-hockey, rooting for the Boston Red Sox, and John Grisham novels.
Dr. Michail Tsakos, Postdoctoral Associate
Ph.D., 2014, National and Kapodistrian University of Athens
Michail was born in Athens, Greece. He holds a BSc in Chemistry from the University of Ioannina and MSc and Ph.D. degrees (2013) in Organic Synthesis from the University of Athens under the supervision of Prof. George Kokotos. His Ph.D. research involved the synthesis of novel organocatalysts and their application in asymmetric organic transformations. Following his graduate studies, he conducted postdoctoral research at Aarhus University (Denmark) with Prof. Thomas Poulsen working on the total synthesis of anti-cancer natural products, and at McGill University with Prof. Youla Tsantrizos focusing on the development of novel enzyme inhibitors. In the Herzon Lab, Michail focuses on the total synthesis of biologically active complex natural products.
Dr. Chao Wang, Postdoctoral Associate
Ph.D., 2016, Tokyo University of Agriculture and Technology
Kevin Wernke, Graduate Student
Born and raised in Grand Junction, Colorado, Kevin attended Colorado Mesa University, where he studied and characterized the effects of natural products in Dictyostelium discoideum in the lab of Professor Kyle McQuade. As an Amgen Scholar at Washington University in St. Louis, Kevin explored the dynamic role of synthetic chemistry in biomedical research, and from this he decided to continue studies in organic synthesis, and pursue a Ph.D. in organic chemistry. Outside the lab Kevin mountain bikes, skis, enjoys music, baking, and plays ultimate frisbee.
Mengzhao (Lucy) Xue
Lucy was born in Ningbo, China. After finishing her middle school at Ningbo Foreign Language School, Lucy came to the US for high school in 2009. In 2012, Lucy graduated from Santiam Christian High School in Oregon and started her undergraduate education in Lehigh University in Pennsylvania. While in Lehigh, she joined a biophysical chemistry lab and studied the secondary structure of the N-terminus domain of caveolin protein. In 2015, Lucy earned her B.S. in Biochemistry from Lehigh and started her Ph.D. in Chemistry in Yale University. Outside the lab, Lucy enjoys reading Chinese literature and writing love stories and romantic poetry.
Mingshuo Zeng, Graduate Student, University Fellowship
BA, 2012, The University of Tokyo
Mingshuo Zeng was born in Jiangxi, China in 1989, and moved to Japan in 1994 with her family. In the spring of 2008 she graduated from Takamatsu High School in Kagawa. Soon after, she entered the University of Tokyo, from where she obtained B.A. in Pharmaceutical Science. There she conducted undergraduate research under the guidance of Professor Tohru Fukuyama, studying the synthesis and bioactivity of compounds related to Neuroligin, a postsynaptic adhesion molecule. After her graduation in 2012, she came to Yale to join the Herzon lab, with a focus on transition metal chemistry.
Samantha Angle, Undergraduate Research Associate
Sam Angle is in the class of 2018 at Yale University. She was born and raised in Middletown, Connecticut and conducted research in organic chemistry at Wesleyan University under the guidance of Professor Brian Northrop during the summers of 2013 and 2014. It was during this experience that she discovered her passion for chemistry. Sam joined the Herzon laboratory in the Summer of 2015.